文章基本信息

标题：A Rice Protein Isolate Alters 7, 12-Dimethylbenz[α]Anthracene-Induced Mammary Tumor Development in Female Rats
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作者：Tatsuya MORITA ; Shuhachi KIRIYAMA
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1996
卷号：42
期号：4
页码：325-337
DOI：10.3177/jnsv.42.325
出版社：Center for Academic Publications Japan
摘要：The effects of a rice protein isolate (RPI) on 7, 12-dimeth-ylbenz[α] anthracene (DMBA)-induced mammary tumor progression were investigated in female Sprague-Dawley rats. At 6 weeks of age, rats were fed a casein, RPI or soybean protein isolate (SPI) diet, respectively. After 1 week, DMBA was administered orally at the dose of 30mg/kg body weight. The mean tumor number per tumor-bearing rat at autopsy was significantly lower only in rats fed RPI than in those fed casein. Palpable tumors at the mid point of the experiment were significantly lower in rats fed RPI and SPI than in those fed casein. Serum estradiol-17β concentrations were lower in rats fed the SPI (but not in those fed RPI) than in those fed casein. In a further experiment, no differences were found in hepatic microsomal DMBA-arylhydrocarbon hydroxylase activity after 7 days of feeding the respective diets. These results suggest that RPI exerts its inhibitory effect on DMBA-induced mammary tumor-igenesis irrespective of changes in circulating estrogens or modulation of hepatic DMBA metabolism.
关键词：breast cancer;dietary protein;rice protein isolate;carcinogens (dimethylbenz [α] anthracene, DMBA);estradiol-17β;fecal steroid excretion;rats