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标题：Effects of Calcium Gluconate on the Utilization of Magnesium and the Nephrocalcinosis in Rats Fed Excess Dietary Phosphorus and Calcium
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作者：Osamu CHONAN ; Rie TAKAHASHI ; Shoichi KADO 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1996
卷号：42
期号：4
页码：313-323
DOI：10.3177/jnsv.42.313
出版社：Center for Academic Publications Japan
摘要：The effects of calcium gluconate on the utilization of mag nesium and nephrocalcinosis in male Wistar rats made magnesium deficient by adding excess dietary phosphorus (1.195g of phosphorus/100g of diet) and calcium (1.04g of calcium/100g of diet) were compared with the effects of calcium carbonate. The effects of dietary magnesium concentration on the magnesium status and nephrocalcinosis were also examined. Adding excess dietary phosphorus and calcium decreased the apparent magnesium absorption ratios and the concentrations of magnesium in the serum and femur and increased the deposition of calcium in the kidney, and the low magnesium condition (0.024g of magnesium/ 100g of diet) aggravated the deposition of calcium and the low magnesium status. The apparent magnesium absorption ratios and femur magnesium concentration in the rats fed a calcium gluconate diet (an equimolar mixture of calcium gluconate and calcium carbonate was used as a source of calcium) were significantly higher than in the rats fed a calcium carbonate diet (only calcium carbonate was used as a source of calcium), irrespective of dietary magnesium concentration. Dietary calcium gluconate lessened the accumulation of calcium in the kidney and increased the serum magnesium concentration compared with dietary calcium carbonate, when the rats were fed the normal magnesium diet (0.049g of magnesium/100g of diet) but not the low magnesium diet. We speculate that the increased utilization of magnesium by feeding the calcium gluconate diet to a limited extent prevented the low magnesium status and the severity of nephrocalcinosis caused by adding excess dietary phosphorus and calcium.
关键词：calcium gluconate;calcium carbonate;magnesium;phosphorus;rat;absorption;deficient;nephrocalcinosis