文章基本信息

标题：Dietary Vitamin B6 Suppresses Colon Tumorigenesis, 8-Hydroxyguanosine, 4-Hydroxynonenal, and Inducible Nitric Oxide Synthase Protein in Azoxymethane-Treated Mice
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作者：Shun-ichiro KOMATSU ; Hiromitsu WATANABE ; Tatsuzo OKA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2002
卷号：48
期号：1
页码：65-68
DOI：10.3177/jnsv.48.65
出版社：Center for Academic Publications Japan
摘要：Recently we reported that the supplementation of vitamin B₆ to low vitamin B₆ diet caused suppression in colon tumorigenesis and cell proliferation of azoxymethanetreated mice in a dose-dependent manner among 1, 7, and 14mg pyridoxine HCl/kg diet (J Nutr 131: 2204-2207, 2001). To examine the mechanism of the anticolon tumor effect of vitamin B₆, male ICR mice were fed the diet containing 1, 7, 14, and 35 mg pyridoxine HCl/kg diet for 22 wk and simultaneously given a weekly injection of azoxymethane for an initial 10 wk. The supplementation of vitamin B₆ to a low vitamin B₆ diet (1 mg pyridoxine HCl/kg) suppressed the levels of colonic 8-hydroxyguanosine and 4-hydroxynonenal and in-ducible nitric oxide synthase protein. The results suggest that the preventive effect of vita-min B₆ against colon tumorigenesis is at least in part mediated by reducing oxidative stress and nitric oxide production.
关键词：vitamin B6;colon tumorigenesis;cell proliferation;oxidative stress;nitric oxide