文章基本信息

标题：Distribution of Geriatric Disease-Related Genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA)
本地全文：下载
作者：Hiroshi Shimokata ; Yoshiji Yamada ; Masanori Nakagawa 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2000
卷号：10
期号：1sup
页码：46-55
DOI：10.2188/jea.10.1sup_46
出版社：Japan Epidemiological Association
摘要：Phenotypes of various genes related to geriatric diseases and the aging process were assessed in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILSLSA). The subjects were 1, 297 participants in the NILS-LSA. They were community-living males and females aged 40 to 79 years who were randomly selected from the area of the NILS. Genotypic and allelic frequencies of genes in the subjects were analyzed. Age and gender differences in the distribution of genotypes were also tested. The genotypic frequencies were as follows: (1) Angiotensin I-converting enzyme (ACE) genotype was I/I 46.2%, l/D 38.3% and DID 15.5%. (2) a 1-adrenoreceptor genotype was C/C 84.4%, C/T 12.7%, and T/T 3.0%. (3) Apolipoprotein E genotype was ε/ ε 0%, ε/ ε3 7.9%, ε3/ ε3 70.0%, ε3/ ε4 20.8%, ε/ ε4 0%, and ε 4/ ε 4 1.4%. (4) Cholecystokinin type-A receptor (CCKAR) nucleotide -81 (nt-81) genotype was A/A 59.1 %, A/G 35.1 %, and GIG 5.9%. The CCKAR nucleotide -128 genotype (nt128) was G/G 74.3%, G/T 23.6%, and T/T 2.2%. The combination of nucleotide (nt-81, nt-128) was (A/A, G/G) 59.1 %, (A/G, G/G) 14.1 %, (G/G, G/G) 1.1 %, (A/G, G/T) 21.0%, (G/G, G/T) 2.6%, and (G/G, T/T) 2.1 %. There were no subjects with (A/A, G/T), (A/A, T/T) or (A/G, T/T) genotypic combinations. (5) β 3-adrenoreceptor genotype was T/T 66.8%, T/A 28.5%, and A/A 4.7%. (6) Dihydrolipoamide succinyltransferase (DLST) nucleotide 19117 genotype was A/A 25.1 %, A/G 49.7%, and G/G 25.1 %. The DLST nucleotide 19183 genotype was C/C 55.8%, C/T 38.2%, and T/T 5.9%. The combination of nucleotide (nt19117, nt19183) was (A/A, C/C) 6.7%, (A/G, C/C) 24.1 %, (G/G, C/C) 25.1 %, (A/G, C/T) 25.6%, (A/A, T/T) 5.9%, and (A/A, C/T) 12.6%. There were no subjects with (A/G, T/T), (G/G, T/T) or (G/G, T/C) genotypic combinations. (7) Transforming growth factor-β 1 genotype T/T 35.2%, T/C 44.6%, and C/C 20.2%. (8) The platelet-activating factor acethylhydrase genotype was MIM 71.7%, M/m 27.2%, and m/m 1.2%. The mitochondria DNA 5178 genotype A was 42.1 % and C was 57.9%. There were no significant gender or age differences in tested genotypic and allelic distribution except for the DLST and apolipoprotein E. Differences in the genotypic frequencies of distribution using the Hardy-Weinberg equilibrium were significant in the ACE and α 1 -adrenoreceptor genotypes. J Epiderniol, 2000 ; 10 : S46-S55.
关键词：aging;geriatric diseases;molecular epidemiology;genotype