文章基本信息

标题：Natural Killer Activity and Its Changes among Participants in a Smoking Cessation Intervention Program -a Prospective Pilot Study of 6 Months' Duration
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作者：Akiko Ioka ; Masakazu Nakamura ; Noriko Shirokawa 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2001
卷号：11
期号：5
页码：238-242
DOI：10.2188/jea.11.238
出版社：Japan Epidemiological Association
摘要：We examined the effect of smoking cessation on natural killer (NK) activity of peripheral blood lymphocytes in terms of a prospective study of 27 Japanese subjects who participated in a smoking cessation intervention program. This program was delivered by means of groupcounseling offering 7 sessions of about 2 hours over 6 months to help smokers to discontinue the habit. Thirteen subjects ceased smoking (quitters), while 14 continued to smoke (cigarette smokers). NK activity before the intervention was correlated positively with age (correlation coefficient=0.46, P<0.05). NK activity remained almost constant among quitters, comparing the activity before and after the intervention, while it decreased among cigarette smokers although it was not statistically significant. In the subgroup analysis, NK activity increased among those aged less than 65 years, or urine cotinine levels over 800 ng/ml before the intervention, especially among quitters, but there were no statistical significances. Multiple regression analysis showed changes in NK activity were correlated significantly only with age (standard regression coefficient=-0.44, P<0.05). These findings suggest that smoking cessation intervention programs might have been more effective for younger than elder subjects in consideration of NK activity. J Epidemiol , 2001 ; 11 : 238-242
关键词：natural killer activity;smoking cessation;age;urine cotinine