文章基本信息

标题：Familial Aggregation of Uterine Myomas in Japanese Women
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作者：Fumio Sato ; Mitsuru Mori ; Motol Nishi 等
期刊名称：Journal of Epidemiology
印刷版ISSN：0917-5040
电子版ISSN：1349-9092
出版年度：2002
卷号：12
期号：3
页码：249-253
DOI：10.2188/jea.12.249
出版社：Japan Epidemiological Association
摘要：To assess the familial aggregation of uterine myomas in Japanese women with myomas, one hundred forty four women requiring surgery for myomas and 288 age-matched healthy controls were studied in Hokkaido, Japan. The incidence of positive first-degree family history of myomas among women aged 45-54 years with myomas was greater than that among controls (31.5% versus 15.2%, respectively, p < 0.01). Analyses categorized by the status of parity and familiality among subjects showed that the risk for myomas was the greatest in women who had both fewer births (parity = 0 or 1 ) and the positive family history of myomas as compared with those who had both more births (parity 2) and the negative familiality of myomas (odds ratio = 5.8, 05% confidence interval = 2.3 --14 8). The results of this study suggest that Japanese middle-aged women with myomas have the familial predisposition of uterine myomas. Furthermore, nulliparous women with the familial aggregation of myomas may be at increased risk of the disease. J Epidemiol , 2002 ; 12 : 240-253
关键词：uterine myomas;familiality;nulliparity