文章基本信息

标题：Pharmacokinetic Interaction of Zonisamide in Rats. Effect of Zonisamide on Other Antiepileptics
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作者：Masahiko KIMURA ; Naomi TANAKA ; Yasuhiro KIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：7
页码：722-725
DOI：10.1248/bpb.16.722
出版社：The Pharmaceutical Society of Japan
摘要：The effects of zonisamide (ZNS) on the pharmacokinetics of phenobarbital (PB), valproic acid (VPA), carbamazepine (CBZ) and phenytoin (PHT) were investigated in rats. Additionally, the influence of ZNS on the serum protein binding, erythrocyte distribution and metabolism of these antiepileptics was studied in vitro. The t_1/2 and AUC values of PB were significantly increased by ZNS coadministration, and a significant decrease in the V_d/F value of PHT was observed after multiple dosing of ZNS. By contrast, ZNS showed no significant effect on VPA and CBZ kinetics. No significant effect of ZNS was observed in the serum protein binding, erythrocyte distribution or metabolism of other antiepileptics. These results suggest that ZNS has little effect on the pharmacokinetic behaviors of other antiepileptic drugs.
关键词：zonisamide;pharmacokinetic interaction;antiepileptic drug;protein binding;erythrocyte distribution;metabolism