文章基本信息

标题：Substrates and Inhibitors of Antiseptic Resistance in Staphylococcus aureus
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作者：Masanori SASATSU ; Yoshiyuki SHIBATA ; Norihisa NOGUCHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：1
页码：163-165
DOI：10.1248/bpb.17.163
出版社：The Pharmaceutical Society of Japan
摘要：The range of substrates of antiseptic resistance associated with the ebr gene is very wide and includes antiseptics, DNA-intercalating drugs and preservatives which have no quaternary ammonium group in methicillin-resistant Staphylococcus aureus. Antiseptic resistance was inhibited by calcium channel blockers and calmodulin inhibitors similarly to the resistance to multiple antitumor agents encoded by the mdr gene in human cells. These results show that the common properties of the mdr gene and the ebr gene may be shared by the mechanisms that are involved in the removal of toxic substances from the cell.
关键词：MRSA;antiseptic resistance;substrate profile;calcium channel blocker;calmodulin inhibitor