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标题：Urinary Levels of γ-Carboxyglutamic Acid and Its Clinical Significance
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作者：Katsuhiro GOTO ; Seiji KATO ; Sadaharu SUMIYA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：1
页码：142-145
DOI：10.1248/bpb.17.142
出版社：The Pharmaceutical Society of Japan
摘要：Urinary γ-carboxyglutamic acid (γ-Gla) levels were determined in healthy subjects of all ages. The urinary γ-Gla levels were highest in infants (0-1 years), then fell in an age-dependent manner, again in subjects reaching a minimum value in adults, then gradually increased over 60 years of age. Urinary γ-Gla levels therefore change markedly with aging. The relationships between the urinary γ-Gla excretion and plasma levels of prothrombin and protein C in patients with various hepatic diseases or diabetes mellitus were examined and compared with those in healthy adults. Both plasma prothrombin and protein C levels were decreased in all patients with liver disease compared with healthy adults. In patients with hepatitis and liver cirrhosis, the decrease did not, however, affect the γ-Gla excretion. In addition, in patients with hepatoma or carcinoma with liver metastases, the urinary γ-Gla levels were increased. In patients with diabetes mellitus, the urinary γ-Gla levels and plasma levels of prothrombin and protein C tended to increase, but this was not significant. The present results indicate that simultaneous measurement of the levels of urinary γ-Gla and plasma prothrombin and protein C is a useful tool for the diagnosis of liver diseases and diabetes mellitus.
关键词：γ-carboxyglutamic acid;prothrombin;protein C;diabetes mellitus;hepatic disease