文章基本信息

标题：Relationship between the Tissue Distribution and Antitumor Activity of Highly Branched (1→3)-β-D-Glucan, SSG
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作者：Masahiro SUDA ; Naohito OHNO ; Yoshiyuki ADACHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：1
页码：131-135
DOI：10.1248/bpb.17.131
出版社：The Pharmaceutical Society of Japan
摘要：Distribution of ³H-labeled (1→3)-β-D-glucan([³H]SSG) obtained from the culture filtrate of Sclerotinia sclerotiorum IFO 9395, in various tissues in tumor-bearing mice was examined. [³H]SSG administered intra-peritoneally was mainly detected in liver, spleen, kidney and tumor masses. In contrast to i.p. administration, intra-lesionally administered [³H]SSG was not released from the tumor. Similarly, in a double grafted tumor system, [³H]SSG was located in the administered tumor and not distributed in the distant site tumor, in spite of the fact that significant antitumor effect was shown in both tumor sites in this system. Winn assay confirmed the activation of the systemic antitumor immunity. These results suggested that the distribution of glucans would be one important factor in determining their antitumor effects. However, this would not always be necessary if systemic immunity could be induced.
关键词：antitumor glucan;Sclerotinia sclerotiorum;[3H]-(1→3)-β-D-glucan;double grafted tumor system;antitumor activity;tissue distribution