文章基本信息

标题：Differential Aging Pattern of Cerebral Accumulation of Radiolabeled Glucose and Amino Acid in the Senescence Accelerated Mouse (SAM), a New Model for the Study of Memory Impairment
本地全文：下载
作者：Yasuhisa FUJIBAYASHI ; Atsuo WAKI ; Kouichi WADA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：1
页码：102-105
DOI：10.1248/bpb.17.102
出版社：The Pharmaceutical Society of Japan
摘要：Using an accelerated senescence-prone model mouse strain, SAMP8, with spontaneously occurring age-related deficits in learning and memory, cerebral glucose and amino acid accumulation were investigated to study the metabolic abnormalities in relation to age. The findings were compared with those in an accelerated senescence-resistant mouse strain, SAMR1, without deterioration of ability in learning and memory.[¹⁴C]-2-Deoxyglucose accumulation in the SAMP8 brain was normal at 1 month of age but decreased from 2-3 months of age onwards. In contrast, tyrosine accumulation was unchanged from 1 to 5 months of age. The impairment of memory in the SAMP8 at 2-3 months of age corresponded with the decrease in [<14>C]-2-deoxyglucose accumulation, but was not related to Tyr. This animal model may help provide new information on the metabolic changes in aging.
关键词：senescence-accelerated mouse (SAM);memory impairment;aging;glucose uptake;amino acid uptake