文章基本信息

标题：Anti-allergy Actions of Alkylphenyl α-D-Mannopyranosides
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作者：Tzer Chuan WANG ; Hisao KAKEGAWA ; Hitoshi MATSUMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：1
页码：93-96
DOI：10.1248/bpb.17.93
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effects of alkylphenyl α-D-mannopyranosides on histamine release from rat peritoneal mast cells induced by an antigen-antibody reaction were examined. Among the compounds tested, 2, 4, 6-trimethylphenyl α-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, the 2, 4, 6-trimethylphenyl α-D-man-nopyranoside suppressed the Schultz-Dale reaction and 48 h homologous passive cutaneous anaphylaxis (PCA), suggesting that this compound may be a useful lead compound in the development of novel anti-allergy drugs.
关键词：aryl mannopyranoside;antigen-antibody reaction;histamine release inhibition;2, 4, 6-trimethylphenyl α-D-mannopyranoside;Schultz-Dale reaction;48 h PCA