文章基本信息

标题：Influences of Alkylphenyl α-D-Mannopyranosides on Histamine Release from Rat Peritoneal Mast Cells Induced by Concanavalin A
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作者：Tzer Chuan WANG ; Hisao KAKEGAWA ; Hitoshi MATSUMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：1
页码：87-92
DOI：10.1248/bpb.17.87
出版社：The Pharmaceutical Society of Japan
摘要：The influence of mannose, glucose, galactose and their corresponding methyl and phenyl glycopyranosides, as well as a series of alkylphenyl α-D-mannopyranosides, on histamine release from rat peritoneal mast cells induced by concanavalin A was examined. Among the compounds tested, the inhibitory effects of compounds bearing a 2, 6-dimethyl substituent were stronger than the others. The results suggest that the binding ability of phenyl α-D-mannopyranoside may be markedly enchanced by the introduction of a 2, 6-dimethyl substituent into the benzene nuclei of aglycones.
关键词：aryl mannopyranoside;2, 3, 6-trimethylphenyl α-D-mannopyranoside;concanavalin A;histamine release;histamine release inhibition