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标题：Urinary Excretion Level of Hydroxylysylpyridinoline as an Index of Bone Resorption
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作者：Kazuhiro YOSHIHARA ; Shigeru NEMOTO ; Minoru NAGATA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：6
页码：840-842
DOI：10.1248/bpb.17.840
出版社：The Pharmaceutical Society of Japan
摘要：Hydroxylysylpyridinoline (HP), an intermolecular cross-linking amino acid, is present only in bone and cartilage collagen. We examined urinary HP levels in order to assess bone collagen metabolism using HPLC. Urinary HP excretion levels (nmol/mmol creatinine) of healthy control groups gradually increased with aging. Urinary HP excretion levels of females were higher than those of age-adjusted males. On the other hand, the urinary excretion levels of HP in osteoporotic patients were significantly higher than those of age and sex-adjusted controls. It is suggested that the determination of urinary HP excretion levels is useful in the clinical evaluation of metabolic bone diseases, especially osteoporosis.
关键词：hydroxylysylpyridinoline;urinary excretion level;osteoporosis;bone resorption;biomedical marker;HPLC