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标题：Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of [D-Ala2] Leu-Enkephalin-Poly (Ethylene Glycol) Hybrid
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作者：Mitsuko MAEDA ; Koichi KAWASAKI ; Tadanori MAYUMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：6
页码：823-825
DOI：10.1248/bpb.17.823
出版社：The Pharmaceutical Society of Japan
摘要：The hybrid of poly (ethylene glycol) and [D-Ala²] Leu-enkephalin was prepared by the solution method and its antinociceptive effect and inhibitory effect on the electrically induced contractions of mouse vas deferens were examined. The hybrid was synthesized by the coupling of Boc-Tyr-D-Ala-Gly-Phe-Leu-OH and amino-poly (ethylene glycol), followed by trifluoroacetic acid treatment. The hybrid showed more potent antinociceptive activity in mice and 120 times higher inhibitory activity in mouse vas deferens preparation than intact [D-Ala²] Leu-enkephalin.
关键词：enkephalin hybrid;antinociceptive effect;poly (ethylene glycol) hybrid;mouse vas deferens