文章基本信息

标题：Intraperitoneal Administration of Senegae Radix Extract and Its Main Component, Senegin-II, Affects Lipid Metabolism in Normal and Hyperlipidemic Mice
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作者：Hiroyuki MASUDA ; Ken OHSUMI ; Mami KAKO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：2
页码：315-317
DOI：10.1248/bpb.19.315
出版社：The Pharmaceutical Society of Japan
摘要：The hypolipidemic effect of Senegae Radix, i.e."Senega, "was investigated in normal and hyperlipidemic mice. The n-butanol fraction of the methanol extract of Senegae Radix (SN) (5mg/kg) significantly reduced the blood triglyceride level of normal mice 7h after intraperitoneal administration (p<0.05) and also significantly reduced the blood triglyceride level of cholesterol-fed mice under similar conditions (p<0.05). SN (5mg/kg) also reduced the blood triglyceride and cholesterol levels after repeated administration to cholesterol-fed mice. SN also decreased the blood triglyceride level in Triton-induced hyperlipidemia. It is suggested that this fraction contains one or more hypolipidemic components including the main triterpenoid glycoside, senegin-II, which significantly reduces the levels of blood triglycerides in normal mice.
关键词：Senegae Radix;Polygalaceae;hypolipidemic effect;triterpenoid glycoside;senegin-II