文章基本信息

标题：Concanamycin B, a Vacuolar H+-ATPase Specific Inhibitor Suppresses Bone Resorption in Vitro
本地全文：下载
作者：JeTae WOO ; Yasuo OHBA ; Kahori TAGAMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：2
页码：297-299
DOI：10.1248/bpb.19.297
出版社：The Pharmaceutical Society of Japan
摘要：Effects of concanamycin B, a specific inhibitor of the vacuolar type H⁺-ATPase (V-ATPase), on the stimulation of bone resorption induced by parathyroid hormone (PTH) were examined in vitro. Concanamycin B was found to inhibit PTH-stimulated osteoclastic pit formation and to suppress the acidification of vacuolar organelles by V-ATPase in the osteoclasts. PTH-stimulated ⁴⁵Ca release from prelabelled chick embryonic calvariae was also inhibited by concanamycin B in a dose-dependent manner. These results suggest that osteoclastic acidification of lacunae by V-ATPase plays an essential role in mineral dissolution and degradation of the organic matrix during bone resorption.
关键词：concanamycin B;vacuolar H+-ATPase inhibitor;bone resorption