文章基本信息

标题：Anti-tumor-Promoting Activities of Triterpenoids from Ferns. I
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作者：Takao KONOSHIMA ; Midori TAKASAKI ; Harukuni TOKUDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：7
页码：962-965
DOI：10.1248/bpb.19.962
出版社：The Pharmaceutical Society of Japan
摘要：To search for possible anti-tumor-promoters (cancer chemopreventive agents), we carried out primary screening of 23 triterpenoid hydrocarbons (1-23) isolated from ferns using an in vitro synergistic assay system. Of these triterpenoids, hop-17(21)-ene (2), neohop-13(18)-eme (3), neohop-12-ene (4), teraxerane (17), multiflor-9(11)-ene(18), multiflor-8-ene (19), glutin-5(10)-ene (21) and taraxastane (23) exhibited remarkable inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Further, compounds 2 and 3 exhibited remarkable anti-tumorpromoting effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test using 7, 12-dimethybenz[α]anthracene (DMBA) as an initiator and TPA as a promoter.
关键词：anti-tumor-promoter;triterpenoid hydrocarbon;hop-17(21)-ene;neohop-13(18)-ene;fern;mouse skin tumor