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标题：PHENYLMERCURY TRANSPORT MEDIATED BY merT-merP GENES OF PSEUDOMONAS K-62 PLASMID pMR26
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作者：Yoshio UNO ; Masako KIYONO ; Toshiyuki TEZUKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：1
页码：107-109
DOI：10.1248/bpb.20.107
出版社：The Pharmaceutical Society of Japan
摘要：The merB-merA-deleted plasmid pMRD141 which contains the intact merT-merP genes of pMRA17 conferred bacterial hypersensitivity not only to Hg²⁺ but also to C₆H₅Hg⁺. The bacterium with pMRD141 took up significantly more C₆H₅Hg⁺ than its isogenic strain with the cloning vector BluescriptII. The hypersensitivity to C₆H₅Hg⁺ seems to be based on hyperaccumulation of toxic C₆H₅Hg⁺ in the absence of detoxifying enzymes encoded by merB and merA. Our results show that bacterial transport of C₆H₅Hg⁺ into the cytoplasm is regulated by merT-merP genes.
关键词：Phenylmercury transport;merT-merP;pMRD141;pMRA17