文章基本信息

标题：Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus
本地全文：下载
作者：Shuichiro KAKIMOTO ; Hiroshi SAITO ; Norio MATSUKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：7
页码：739-742
DOI：10.1248/bpb.20.739
出版社：The Pharmaceutical Society of Japan
摘要：Emetic and antiemetic effects of morphine were investigated in Suncus murinus. Subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 μg) of morphine failed to cause emesis. However, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), copper sulfate (40 mg/kg, p.o.), cisplatin(20 mg/kg, i.p.) and motion stimulus. These results suggest that morphine has only antiemetic potency and may block a common mechanism for the emetic reflex of suncus, because the antiemetic effects of the drug were exerted irrespective of the stimulus.
关键词：emesis;morphine;antiemetic;motion sickness;Suncus