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标题：Hepatoprotective Effect of Fe-TPEN on Carbon Tetrachloride Induced Liver Injury in Rats
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作者：Jeon-Ok MOON ; Su-Kyung PARK ; Tetsuo NAGANO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：3
页码：284-288
DOI：10.1248/bpb.21.284
出版社：The Pharmaceutical Society of Japan
摘要：Fe(II)-tetrakis-N, N, N', N'(2-pyridylmethyl) ethylenediamine (Fe-TPEN) catalyzes the dismutation of superoxide, and blocks the toxic effect of paraquat on Escherichia coli growth and survival. We examined antioxidative effects of Fe-TPEN on lipid peroxidation and t-butyl hydroperoxide induced cell damage. Fe-TPEN inhibited the FeSo₄/H₂O₂ induced lipid peroxidation in the rat liver homogenates with an IC₅₀ value of 30.2 μM, and protected Ac2F cell damage by t-butyl hydroperoxide in a dose-dependent manner (EC₅₀ value is 2.6 μM). Also, hepatoprotective effect of Fe-TPEN (5 mg/kg, i.p.) was investigated using CCl₄ induced liver injury in rats. This complex inhibited the elevation of serum alanine aminotransferase (AST) and aspartate aminotransferase (ALT) levels in CCl₄ induced liver injuries, and improved submassive necrosis and fatty degeneration of the hepatocytes. Fe-TPEN also prevented the loss of total and nonprotein SH contents, glutathione peroxidase and glutathione-S-transferase activity in cytosol of rat liver. Although the exact mechanism of action is not clear, antioxidative properties as well as attenuation of hepatocellular defense systems by Fe-TPEN seem to be important on its potent hepatoprotective effect in CCl₄-intoxicated rat.
关键词：Fe-TPEN;hepatoprotective effect;antioxidative effect