文章基本信息

标题：Changes in Serum Levels of Sialoglycoproteins in Mice Exposed to UV-B Radiation
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作者：Kiichi YAMAMOTO ; Takako FURUYA ; Yosuke KAMEOKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：9
页码：1000-1002
DOI：10.1248/bpb.21.1000
出版社：The Pharmaceutical Society of Japan
摘要：In the actue phase reaction, hepatocytes in the liver are activated and increase the plasma levels of acute phase reactants. Our previous study has shown that plasma sialic acid, an acute phase reactant, was increased following exposure of mice to UV-B radiation. Plasma sialic acid is derived from many plasma components. To clarify the type of plasma sialic acid that is increased by exposure to UV-B radiation, we performed two-dimensional electrophoresis and staining for sialic acid. Consequently, the increases in haptoglobin and hemopexin were marked and 90% or more of the increased sialic acid was derived from these two glycoproteins after exposure to UV radiation. The increase in α₁-acid glycoprotein levels was slight and did not contribute to the total increase in plasma sialic acid after exposure to UV radiation. Plasma levels of several proteins including antichymotrypsin (ACT), were reduced following exposure to UV radiation. The discrepancy between our results and published ones regarding ACT levels are discussed in terms of the type of cytokine.
关键词：UV-B;acute phase reactant;sialoglycoprotein;haproglobin;hemopexin;sialic acid staining