文章基本信息

标题：Anti-carcinogenic Activity of the Roots of Panax notoginseng. II
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作者：Takao KONOSHIMA ; Midori TAKASAKI ; Harukuni TOKUDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：10
页码：1150-1152
DOI：10.1248/bpb.22.1150
出版社：The Pharmaceutical Society of Japan
摘要：The extract of the roots of Panax notoginseng (Araliaceae) exhibited a significant anti-tumor-promoting activity on two-stage carcinogenesis of mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA) as an initiator and a mycotoxin, fumonisin B1, as a non-12-O-tetradecanoylphorbol-13-acetate (non-TPA) type promoter. Further, the extract exhibited the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) as an intiator and TPA as a promoter.
关键词：anti-carcinogenic activity;Panax notoginseng;fumonisin B1;(±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1);anti-tumor-promoter;anti-tumor-initiator