文章基本信息

标题：Inhibition of LysoPAF Acetyltransferase Activity by Components of Licorice Root
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作者：Seiji NAGUMO ; Akira FUKUJU ; Mitsue TAKAYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：10
页码：1144-1146
DOI：10.1248/bpb.22.1144
出版社：The Pharmaceutical Society of Japan
摘要：Licorice root traditionally used as an anti-inflammatory drug exhibited an inhibitory effect on lysoPAF (platelet-activating factor) acetyltransferase in vitro : the ether soluble fraction of the crude drug produced a 27.3% inhibition at a concentration 10 μg/ml. From this fraction, licorcidin (1), 1-methoxyphaseollin (2), 6, 8-diprenylgenistein (3) and 1-methoxyphaseollidin (4) were isolated as active components, whose IC₅₀ values were 7.7, 57 19 and 48 μM, respectively. Licoricidin (1) seems to be one of the most potent compounds of plant origin isolated so far.
关键词：lysoPAF acetyltransferase;licorice root;isoflavonoid;licoricidin;platelet-activating factor