文章基本信息

标题：Effect of Dai-kenchu-to on Levels of 3 Brain-gut Peptides (Motilin, Gastrin and Somatostatin) in Human Plasma
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作者：Toshiaki NAGANO ; Hiroki ITOH ; Masaharu TAKEYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：10
页码：1131-1133
DOI：10.1248/bpb.22.1131
出版社：The Pharmaceutical Society of Japan
摘要：We examined the effect of Dai-kenchu-to (DKCT), a traditional Chinese (Kampo) medicine, on the levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in plasma from 24 healthy subhects. A single oral administration of DKCT, at a dose of 7.5 g, caused significant increases in plasma motilin levels (about 12 pg/ml) at 60 to 90 min, compared with a placebo-treated group. Transient elevations of gastrin levels were noted after administration of both DKCT (25.9±1.4 pg/ml) and placebo (23.5±1.3 pg/ml). DKCT did not alter the levels (about 5.7 pg/ml) of somatostatin. In conclusion, these results indicate that the action of DKCT closely relates to changes in motilin-immunoreactive substance levels in human plasma.
关键词：motilin;Dai-kenchu-to;Kampo;gastrin;somatostatin;gastrointestinal motility