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标题：Two Flavonoids from the Leaves of Mours alba Induce Differentiation of the Human Promyelocytic Leukemia (HL-60) Cell Line
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作者：Sun Yeou KIM ; Jian Jun GAO ; Hee Kyoung KANG 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：4
页码：451-455
DOI：10.1248/bpb.23.451
出版社：The Pharmaceutical Society of Japan
摘要：Two flavonoids, quercetin-3-O-β-D-glucopyranoside (1) and quercetin-3, 7-di-O-β-D-glucopyranoside (2), were isolated from the leaves of Mours alba (Moraceae). These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2×10^-4 M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens. These flavonoids exhibited significant free radical scavenging effects on 1, 1-diphenyl-2-picyl-hydrazyl radical.
关键词：mulberry leaf;flavonoid;differentiation