文章基本信息

标题：Effects of Fujibitol, a Remedy for Nasal Symptoms, on Experimental Allergic Rhinitis in Rats
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作者：Masanori KAKIMOTO ; Yukio SUGIMOTO ; Michiko HARADA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：9
页码：1055-1058
DOI：10.1248/bpb.23.1055
出版社：The Pharmaceutical Society of Japan
摘要：The effects of Fujibitol, a preparation of crude drugs in wide clinical use for treatment of chronic rhinitis and empyema, on experimental allergic rhinitis in rats were studied. Fujibitol inhibited nasal allergic symptoms, i.e. sneezing and nasal rubbing, induced by antigen in sensitized animals. An increase in dye leakage into the nasal cavity induced by antigen was also inhibited by Fujibitol. On the other hand, no inhibitory effects were observed on either the nasal allergic symptoms or increase in dye leakage into the nasal cavity induced by histamine. However, Fujibitol was effective in inhibiting histamine release from the nasal cavity induced by antigen. Oxatomide used as positive control drug showed potent inhibitory effects on nasal symptoms and dye leakage into the nasal cavity induced by histamine and antigen. These results suggested that Fujibitol showed a remarkable protective effect against experimental rhinitis induced by antigen via inhibition of histamine release from the nasal cavity.
关键词：Fujibitol;allergic rhinitis;nasal symptoms;increase in dye leakage