文章基本信息

标题：Hepatoprotection by Human Epidermal Growth Factor (hEGF) against Experimental Hepatitis Induced by D-Galactosamine (D-GalN) or D-GalN/Lipopolysaccharide
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作者：Jae Youl CHO ; Je Duck YEON ; Jeom Yong KIM 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：10
页码：1243-1246
DOI：10.1248/bpb.23.1243
出版社：The Pharmaceutical Society of Japan
摘要：The hepatoprotective effects of recombinant human epidermal growth factor (hEGF) on chemically and immunologically induced experimental liver injury models were examined. The hEGF clearly decreased serum transaminase levels in D-galactosamine (D-GalN) and D-GalN/lipopolysaccharide (LPS)-induced liver injury models under sub-lethal conditions. However, it has not significantly changed either serum or in vitro tumor necrosis factor (TNF)-α production or in vitro nitric oxide (NO) production, suggesting that the hepatoprotection by EGF is not mediated by inhibiting these pathological mediators produced in D-GalN and D-GalN/LPS-induced liver injury.
关键词：human epidermal growth factor (hEGF);hepatoprotective effect;liver injury cytotoxic molecules