文章基本信息

标题：RESPONSES OF ALVEOLAR MACROPHAGE TO METALLIC FUME
本地全文：下载
作者：Kimiko KOSHI ; Katsunori HOMMA ; Hiroyuki SAKABE 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1975
卷号：13
期号：1-2
页码：37-49
DOI：10.2486/indhealth.13.37
出版社：National Institute of Occupational Safety and Health
摘要：Alveolar macrophage was lavaged from lungs of rats exposed to inhalation of the particles of Sb, Pb, Cd, CaCO₃ or poly vinyl chloride (PVC) and its number and ¹⁴C-leucine incorporating activity were studied. The number of free cell lavaged from the lung decreased remarkably by the exposure to Sb or Cd fume, while by the exposure to Pb fume, CaCO₃ or PVC particles the number of lavaged cells did not change from that of control group breathing air in the exposure chamber. There was found a linear correlation 1 hr after inhalation between ¹⁴C-leucine in-corporation value for total cell and the number of lavaged cell in all the experi-mental groups except unrestrained (bred freely under normal condition) group and Sb group. That is, the incorporation value per cell in all the experimental groups except Sb group and unrestrained group was almost equal. In the case of Sb group and unrestained group the incorporation value per cell was lower than those of the other groups. Although the incorporation of ¹⁴C-leucine into cell in control group decreased by level of unrestrained group 21 hr after inhalation, in the Pb, CaCO₃ or PVC group ¹⁴C-leucine incorporation into cell 21th hour did not change from that 1 hr after inhalation. ¹⁴C-leucine incorporation per cell in Sb group 21 hr after inhalation remarkably increased. This tendency was also seen in Cd group. The effects of the particles used in the inhalation experiment on the macrophage in vitro were also studied. The Sb fume was the most effective of all the samples and followed by Cd fume and then by Pb fume. The particles of CaCO³ or PVC were practically inert to the macrophage.