文章基本信息

标题：The Effects of Dioxin on Reproduction and Development
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作者：Junzo YONEMOTO
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2000
卷号：38
期号：3
页码：259-268
DOI：10.2486/indhealth.38.259
出版社：National Institute of Occupational Safety and Health
摘要：The developmental effects of dioxin are important because of the high sensitivity of mammals as well as the irreversibility and longevity of the effects. In animal experiments, exposure to dioxin during pregnancy and lactation induce various functional effects on offspring at very low doses. In humans, even if there is no exposure to dioxin after birth, there might be effects on thyroid function in infants exposed to dioxin from breast milk. In this report, low-dose developmental effects of dioxins on offspring in animal experiments and human studies were reviewed. In terms of risk assessment, methods to describe dosimetry, models to describe dose-response and approaches to express health risk are discussed.
关键词：Dioxin;TCDD;Reproductive effects;Developmental effects;Risk assessment;Breast milk