文章基本信息

标题：Short Term Effect of Silicon Carbide Whisker to the Rat Lung
本地全文：下载
作者：Akira OGAMI ; Yasuo MORIMOTO ; Hiroshi YAMATO 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2001
卷号：39
期号：2
页码：175-182
DOI：10.2486/indhealth.39.175
出版社：National Institute of Occupational Safety and Health
摘要：We studied the short-term effect of silicon carbide whisker (SiCW) in vivo by instillation and inhalation to the rat lung. SiCW was instilled low dose (2 mg/0.5 ml saline) or high dose (10 mg/ 0.5 ml) intratracheally into the lungs of 25 rats. SiCW was also inhaled to another 25 rats at the average concentration of 10.4 mg/m³ for 1 month. In instillation study, the lung had focal alveolitis with the destruction of alveolar wall especially at 3 days after the instillation, and the lesion remained as an aggregated foci of SiCW at 6 months. The 'inflammation-score' of the instilled group by point counting method of the specimen correspondingly decreased gradually. In inhalation group, a minimum inflammatory change was observed. Collagen deposition in the aggregated foci of SiCW with accumulated alveolar macrophages and neutrophils was not progressive during the observed period. These findings suggest that SiCW may cause a minor effect to the rat lung in 6 months after exposure.
关键词：Silicon carbide whisker;Lung pathology;Inhalation;Instillation