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标题：Morphometric Study on Age-Dependent Pulmonary Lesions in Rats Exposed to Nitrogen Dioxide
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作者：Hiroko KYONO ; Kiyoyuki KAWAI
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1982
卷号：20
期号：2
页码：73-99
DOI：10.2486/indhealth.20.73
出版社：National Institute of Occupational Safety and Health
摘要：Electronmicroscopic morphometry was performed on lung of 1, 3, 12 and21 months-old rats exposed to 0.1, 0.5, 3 and 10 ppm nitrogen dioxide (NO₂) continuously for one month. The rats used in this experiment were all supplied at one time from one colony and kept uder a barrier system until exposure. Effects of aging on the responses of lungs to NO2 were studied by comparingthe dose-effect reaction patterns among the age groups. A trend of dose-dependent increase of arithmetic mean thickness of air-blood barrier was found in all age groups examined. The responses of lung to NO₂ ex-posure showedage-related differences. Based on the morphometric index, the response declines from 1 to 12 months, but increases again in 21-months-old rats. The compartmental components of alveolar wall tissue such as type I epithelial cells, type II epithelial cells, interstitial cells, interstitial matrix and capillary en-dothelium appeared to have various degrees of response due to both age at onset of exposure and NO₂ concentration, resulting in the appearance of varying stages in impairment or repair. Accordingly, the response of each compartmental com-ponent of lung to the concentrations of NO₂ did not always exhibit a simple dose-dependent increase or decrease but sometimes indicated a multiphasic reaction pattern.
关键词：NO2;Aging;Pulmonary lesion;Morphometry