文章基本信息

标题：Some Aspects of Metabolism and Mutagenicity of o-Tolidine and an o-Tolidine-based Azo Dye
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作者：Ken-ichi TANAKA ; Toshiko MII ; Ikuo MATSUBARA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1982
卷号：20
期号：3
页码：227-235
DOI：10.2486/indhealth.20.227
出版社：National Institute of Occupational Safety and Health
摘要：Mutagenicity of the urine extracts of the rats to which either o -tolidine or Evans Blue, an o -tolidine-based azo dye, had been orally given was assayed in the Salmonella/mammalian-microsome test. The urine extracts obtained from the rats treated with o -tolidine showed stronger mutagenicity than o -tolidine itself. While Evans Blue did not show mutagenicity at all, the urine extracts derived from the substance were found mutagenic. Both 3, 3'-dimethyl- N -acetylbenzidine and 3, 3'-dimethyl- N , N '-diacetylbenzidine were identified as urinary metabolites of o -tolidine. They were found not only in the urine of the rats treated with o -tolidine but also in the urine of the rats to which Evans Blue had been orally administered. The experimental results suggest that the accidental intake of biphenyl-based dyestuffs through the mouth should be cautiously avoided. Some aspects of the metabolism of o -tolidine and Evans Blue are discussed along with the problem associated with the mutagenic activities of the o -tolidine metabolites.
关键词：o-tolidine;3,3'-dimethyl-N-acetylbenzidine;3, 3'-dimethyl-N,;N'-diacetylbenzidine;Evans Blue;Benzidine;N-acetylbenzidine;N, N'-diacetylbenzidine-Mutagenicity;Urinary metabolites