文章基本信息

标题：臭素酸カリウムと還元型グルタチオンの反応による活性酸素種の発生と脂質過酸化反応
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作者：渡辺聡 ; 宮坂一善 ; 川名清子等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1993
卷号：39
期号：5
页码：445-452
DOI：10.1248/jhs1956.39.5_445
出版社：The Pharmaceutical Society of Japan
摘要：Potassium bromate (KBrO₃), a food additive, has renal toxicity with the possibility of active oxygen species. It was recognized with the DTNB method that the reduced glutathione (GSH) content in the reaction mixture was correlatively decreased by the addition of KBrO₃. The peroxidation of linoleic acid micelle by the addition of GSH and KBrO₃ was measured by the ultraviolet absorption method and oxygen electrode method. Moreover, thiobarbituric acidreactive substance (TBARS) content was correlatively increased by the addition of GSH and KBrO₃ on the microsomal system in vitro. But the increase of TBARS content was inhibited by the addition of sodium azide and it was not inhibited by the addition of superoxide dismutase, catalase, mannitol, uric acid, DTPA and EHPG respectively. The addition of sodium azide correlatively inhibited the production of TBARS in the reaction mixture. These results suggested that the singlet oxygen was produced by the reaction of GSH and KBrO₃ and was related to the lipid proxidation.
关键词：potassium bromate;singlet oxygen;lipid peroxidation;reduced glutathione;sodium azide