文章基本信息

标题：二酸化塩素によるポリオウイルスの不活化作用
本地全文：下载
作者：立川眞理子 ; 濟田清隆 ; 手塚雅勝等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1993
卷号：39
期号：6
页码：572-576
DOI：10.1248/jhs1956.39.6_572
出版社：The Pharmaceutical Society of Japan
摘要：The inactivation rate of poliovirus (Lsc, 2ab strain) suspended in a cell maintenance medium (MEM) and in phosphate buffer salt solution (PBS) with chlorine dioxide (ClO₂), and chlorite ion (ClO₂^-), of 0.4, 1.0 and 2.0 mg/l as available chlorine were studied at pH 7 and 20°C. The residual ClO₂ and ClO₂^- formed in the test solution were determined. The decrease of residual ClO₂ and the formation of ClO₂^- in MEM virus suspension were greater than those in PBS virus suspension. In the lower concentration of ClO₂ (0.4 mg/l), the decrease of ClO₂ in MEM virus suspension resulted in a slower inactivation. With 2.0 mg/l of ClO₂, 99% of the virus was inactivated in about 2 min in both virus suspensions. Chlorite ion (2.0 mg/l) had little effect on the inactivation of the virus in 15 min contact. The inactivation rate with 2.0 mg/l of ClO₂ was almost the same with that with 0.4 mg/l of HOCl reported in a previous paper. The similar inactivation efficiency may be due to almost the same redox potentials (E₀ (V)) of ClO₂ and HOCl, and due to the equal oxidizing capacities of 2.0 mg/l of ClO₂ and 0.4 mg/l of HOCl in the test solution in the neutral pH range.
关键词：virus inactivation;chlorine dioxide;chlorite ion;virus suspension;hypochlorous acid