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标题：Acute Effects of Organotins on Brain, Liver and Kidney in Rats
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作者：R. S. DWIVEDI ; G. KAUR ; R. C. SRIVASTAVA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1985
卷号：23
期号：1
页码：9-15
DOI：10.2486/indhealth.23.9
出版社：National Institute of Occupational Safety and Health
摘要：Effects of dioctyltin oxide (DOTO) tricyclohexyltin hydroxide (TCHTOH) and tributyltin oxide (TBTO) were examined on some enzymic activities in liver and kidney and biogenic amines level in brain of rats at 24 hours after single subcutaneous administration (25 μmole/100 g B. Wt.). All the organotin compounds produced a significant increase in the activity of alkaline phosphatase and adenosin triphosphatase and decrease in monoamine oxidase in both liver and kidney. DOTO and TCHTOH were more effective in impairing the activity of succinate dehydro-genase in liver. Concentrations of γ-aminobutyric acid (GABA) and dopamine were found to be significantly decreased in brain however, acetylcholine concentration remained unaltered. These results suggest that organotin compounds DOTO and TCHTOH are more toxic to rats than TBTO.
关键词：Organotin Compounds;Toxicity;Sulfhydryl;Oxidative Phosphoryl;ation;GABA;Dopamine;Acetylcholine