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标题：Role of Tin on Heme and Drug Biotransformation Mechanism of Partially Hepatectomized Rats
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作者：R. S. DWIVEDI ; G. KAUR ; R. C. SRIVASTAVA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1985
卷号：23
期号：1
页码：1-7
DOI：10.2486/indhealth.23.1
出版社：National Institute of Occupational Safety and Health
摘要：Some parameters of heme and drug-metabolism were measured in sham and partially-hepatectomized rats following a single intraperitoneal injection of tin (II) tartrate (2 mg tin/100 g B. Wt.). One day after treatment, tin, in partially hepatectomized rats produced a depression of activities of delta-aminolevulinic acid synthetase and delta-aminolevulinic acid dehydratase, and induction of heme oxygenase. These changes were accompanied by the marked reduction in the levels of cytochrome P-450 and benzo (a) pyrene hydroxylase. Accumulation of tin measured by incorporation of ¹¹³tin was 23% less in liver of hepatectomized rats than sham-operated rats, however the accumulation of ¹¹³tin in microsomal fraction was much higher in partially hepatectomized rats.
关键词：113Tin;Sham;Partial hepatectomy;Heme meta;bolism;Drug metabolism;Cyrochrome P-450;Rat;RRL