文章基本信息

标题：Adaptation of Extrapulmonary Responses to Ozone Exposure in Conscious Rats
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作者：Takeshi IWASAKI ; Masaya TAKAHASHI ; Hiroyuki SAITO 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1998
卷号：36
期号：1
页码：57-60
DOI：10.2486/indhealth.36.57
出版社：National Institute of Occupational Safety and Health
摘要：The adaptation of cardiovascular and thermoregulatory responses to ozone (O₃) was examined by repeated exposure of electrocardiographic (ECG) electrode- and thermistor sensor-mplanted rats to O₃ for 4 consecutive days (8hrs/day). Circadian rhythms of heart rate (HR) and abdominal core temperature (Tco) were disrupted on the first and second O₃ exposure days in a concentration dependent manner. The 8-hr and 12-hr averaged values of HR and Tco during the exposure period and the dark post-exposure period, respectively, decreased significantly on the first and second exposure days. The decreased HR and Tco recovered to respective control values after small but significant rebound increases on the third and fourth days of O₃ exposure. The adaptation of the extrapulmonary responses to O₃ exposure was discussed in light of the previously reported time periods required to abolish the spontaneous breathing, biochemical, cellular, and morphological responses to O₃.
关键词：Ozone;Rat;Heart rate;Body temperature;Repeated exposures;Adaptation;Circadian rhythm