文章基本信息

标题：Influence of 2-Bromopropane on Reproductive System- 2-Bromopropane Inhibits Forced Ovulation in Mice
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作者：Soichiro SEKIGUCHI ; Takeshi HONMA
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1998
卷号：36
期号：3
页码：297-299
DOI：10.2486/indhealth.36.297
出版社：National Institute of Occupational Safety and Health
摘要：The influence of 2-bromopropane, an alternative to freon, on ovulation was examined using superovulation induced by pregnant mare's serum gonadotropin and human chorionic gonadotropin (PMSG-hCG) treatment. Three groups of mice were injected intraperitoneally 8 times with 2-bromopropane (2-BP) at 500, 1, 000 or 2, 000mg/kg and were induced to ovulate by PMSG-hCG treatment. Injection of 2-BP caused the number of ovulated ova in the 1, 000mg/kg and 2, 000mg/kg groups to decrease remarkably. Uterus weight was also decreased in the 2, 000mg/kg group on the terminal day of the experiment. This result was consistent with cases of human intoxication in which reproductive toxicity was observed.
关键词：2-Bromopropane;Superovulation;PMSG;hCG;Mice