文章基本信息

标题：Cholinesterase Activity in Quails of Neuropathy Caused by Organophosphates
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作者：Hideo KINEBUCHI ; Kunihiro AKIMARU ; Shin-ichiro NODA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1998
卷号：36
期号：4
页码：376-379
DOI：10.2486/indhealth.36.376
出版社：National Institute of Occupational Safety and Health
摘要：It is known that some organophosphates produce not only well-known acute toxicity but also characteristic delayed neurotoxicity. Tri- ortho -tolyl phophate (TOTP), which was formerly named Tri- ortho -cresyl phosphaete (TOCP), was first noticed in an incident of poisoning as the compound which produced organophosphate induced delayed neurotoxicity (OPIDN). It is said that triphenyl phosphite (TPP) is also one of the organophosphates which possesses OPIDN. However, it is thought that TPP-induced delayed neurotoxicity (TPP-DN) is not identical with classical OPIDN. An intermediate syndrome was later proposed as the third neurotoxicity caused by organophosphates. We think that TPP is a Model chemical of the third neurotoxicity. We compared TOTP with TPP using Japanese quails. We Measured cholinesterase (ChE) activity and clearly demonstrated the difference between the two chemicals, that is to say, the activity recovered after 72hrs from the administration of TPP, whereas the inhibition continued for More than 11days after the administration of TOTP.
关键词：Organophosphate induced delayed neurotoxicity;Intermediate syndrome caused by organophosphate;Tri-ortho-tolyl phosphate;Triphenyl phosphite;Cholinesterase activity