文章基本信息

标题：Inducible Nitric Oxide Synthase Expression in Mercury Chloride-Induced Acute Tubular Necrosis
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作者：Hiroyuki YANAGISAWA ; Makoto NODERA ; Osamu WADA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1998
卷号：36
期号：4
页码：324-330
DOI：10.2486/indhealth.36.324
出版社：National Institute of Occupational Safety and Health
摘要：To examine the mechanisms involved in the progression of mercury chloride (HgCl₂)-induced acute tubular necrosis (ATN), we investigated the histopathological changes and the expression of inducible nitric oxide synthase (iNOS) mRNA and protein in renal cortices of rats at 20 hours after exposure to HgCl₂. The expression of iNOS mRNA was significantly augmented in renal cortices of rats with HgCl₂-induced acute renal failure (ARF). Likewise, the induction of iNOS protein was observed in damaged proximal tubule epithelial cells of rats with HgCl₂-induced ARF. Pretreatment of rats with iNOS inhibitor aminoguanidine, however, suppressed the development of proximal tubule epithelial cell injury and prevented an increase in blood urea nitrogen and serum creatinine as well as resulting in a marked fall in iNOS mRNA and protein in rats with HgCl₂-induced ARF. These observations indicate that the induction of iNOS may play a role in the progression of HgCl₂-induced ATN through the exacerbation of proximal tubule epithelial cell damage.
关键词：Mercury chloride;Acute tubular necrosis;Acute renal failure;Inducible nitric oxide synthase;Aminoguanidine