文章基本信息

标题：Imbalance of Testosterone Level in Male Offspring of Rats Perinatally Exposed to Bisphenol A
本地全文：下载
作者：Sumiko WATANABE ; Rui-Sheng WANG ; Muneyuki MIYAGAWA 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：2003
卷号：41
期号：4
页码：338-341
DOI：10.2486/indhealth.41.338
出版社：National Institute of Occupational Safety and Health
摘要：The purpose of this study was to investigate whether exposure to bisphenol A (BPA) through the placenta and milk has any effect on the reproductive system in male offspring. Pregnant rats were treated with BPA at 0, 4, 40 and 400 mg/kg body weight, from gestation day 6 through lactation day 20 by gavage. Plasma testosterone concentrations in offspring at 9 weeks old were significantly high in BPA groups as compared with those of the control. At the age of 36 weeks the hormone concentrations showed an increase in a dose-dependent manner, although without statistical significance. Testosterone content in testes showed a similar tendency to that in plasma, though statistically insignificant. Little alteration in testes weight was seen in BPA-exposed offspring. There was no remarkable change in plasma concentrations of luteinizing hormone and follicle-stimulating hormone at 9 weeks old. The pathway of E₂ (17β-estradiol) formation from testosterone seemed not to be affected by BPA. The results indicate that exposure to BPA during the perinatal period has a significant effect on testosterone homeostasis in male offspring of rats.
关键词：Bisphenol A;Testosterone;Offspring;Perinatal exposure;Male rat