文章基本信息

标题：Inhibitory Effects of Organotin Compounds on Histamine Release from Rat Serosal Mast Cells
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作者：Hideaki IWAI ; Motohiro KUROSAWA ; Hisao MATSUI 等
期刊名称：Industrial Health
印刷版ISSN：0019-8366
电子版ISSN：1880-8026
出版年度：1992
卷号：30
期号：2
页码：77-84
DOI：10.2486/indhealth.30.77
出版社：National Institute of Occupational Safety and Health
摘要：Tributyltin inhibited compound 48/80-induced histamine release from rat serosal mast cells in a dose-related manner. Triphenyltin and tripropyltin also showed a strong inhibitory effect on the histamine release and the degree of the inhibition was the same as that of tributyltin. The inhibitory effects of other organometals were much smaller than those of the organotins. Tributyltin and triphenyltin also showed a tendency to inhibit histamine release induced by concanavalin A + phosphatidylserine and calcium ionophore A 23187. The present results suggest that certain triorganotin compounds may have a specific inhibitory effect on histamine release by acting on the same process in each of the three stimulus responses.
关键词：Organotin;Tributyltin;Triphenyltin;Rat mast cell;Histamine release;Compound 48/80