文章基本信息

标题：Therapeutic Efficacy of a Few Diesters of Meso 2, 3-Dimercaptosuccinic Acid during Sub-Chronic Arsenic Intoxication in Rats
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作者：S.J.S. FLORA ; B.P. PANT ; Neelima TRIPATHI 等
期刊名称：Journal of Occupational Health
印刷版ISSN：1341-9145
电子版ISSN：1348-9585
出版年度：1997
卷号：39
期号：2
页码：119-123
DOI：10.1539/joh.39.119
出版社：Japan Society for Occupational Health
摘要：Therapeutic Efficacy of a Few Diesters of Meso 2, 3-Dimercaptosuccinic Acid during Sub-Chronic Arsenic Intoxication in Rats: S.J.S. FLORA, et al. Division of Pharmacology and Toxicology, Defence Research and Development Establishment —The therapeutic efficacy of four diesters derivatives of meso 2, 3-dimercaptosuccinic acid (DMSA) was investigated in subchronic arsenic intoxication in rats. Dimethyl DMSA (DMDMSA), diethyl DMSA (DEDMSA), diisopropyl DMSA (DiPDMSA) and diisoamyl DMSA (DiADMSA) were the diesters of DMSA with methyl, ethyl, isopropyl and isoamyl alcohols and were administered for two 5 day courses of treatment in male rats pre-exposed to 100 ppm arsenic (III) for 8 weeks. The results show that treatment with these diesters was effective in decreasing blood and soft tissue arsenic contents but was only moderately effective in recovering biochemical indicators. The results suggest that these diesters could be effective arsenic chelators but may be inferior to DMSA in recovering biochemical/clinical indicators following sub-chronic arsenic exposure. ( J Occup Health 1997; 39: 119-123 )
关键词：Arsenic toxicity;Sub-chronic exposure;Biochemical alteration;Arsenic concentration;Chelation;Diesters;Rats