文章基本信息

标题：BENEFICIAL EFFECT OF METHIONINE AND THREONINE SUPPLEMENTS ON TYROSINE TOXICITY IN RATS
本地全文：下载
作者：Yukiko YAMAMOTO ; Hirokazu KATAYAMA ; Keiichiro MURAMATSU 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1976
卷号：22
期号：6
页码：467-475
DOI：10.3177/jnsv.22.467
出版社：Center for Academic Publications Japan
摘要：The growth retardation and external pathological lesions that occur in rats fed a 10% casein diet containing 5% tyrosine could be alleviated by the supplementation of extra protein (20% casein) or 0.66% methionine plus 0.90% threonine (equivalent to the contents in a 20% casein, . respectively). Liver tyrosine aminotransferase activity is elevated by ingestion of excess tyrosine, but lowered by the supplementa tion of extra casein or methionine plus threonine. In rats fed a high tyrosine diet supplemented with methionine plus threonine, liver p -hydroxyphenylpyruvate hydroxylase activity was not higher than that of the 10% casein group, but liver homogentisate oxidase activity in creased significantly. When excess tyrosine was included in the 10 casein diet, free tyrosine concentrations in plasma, liver, muscle and brain were extremely elevated, but when the high tyrosine diet was sup plemented with extra casein or methionine: plus threonine, theirr plasma and tissues tyrosine concentrations lowered significantly. A large in, crease in total phenols, p -hydroxyphenylpyruvate and free tyrosine excretions in urine was produced in animals fed the high tyrosine-low protein diet, but these were lowered by the supplementation of methio nine and threonine to the diet.