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标题：FURTHER STUDIES ON THE REDUCTION OF VITAMIN A CONTENT IN THE LIVERS OF RATS GIVEN POLYCHLORINATED BIPHENYLS
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作者：Satoshi INNAMI ; Atsuko NAKAMURA ; Motoyoshi MIYAZAKI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1976
卷号：22
期号：6
页码：409-418
DOI：10.3177/jnsv.22.409
出版社：Center for Academic Publications Japan
摘要：Further investigations on the, reduction of vitamin A content in the liver of rats fed a 0.1% PCB diet were conducted. The first experiment, in which rats were fed a 0.1% PCB diet for 8 weeks and vitamin A in the liver was determined at 2-week intervals, suggested that a significant decrease of vitamin A in the liver might occur within 2 weeks of PCB ingestion. In the second experiment a significant reduction of vitamin A content per gram of liver, but not per whole liver, in rats fed a 0.1% PCB diet was observed on the 3rd day of PCB ingestion, and then on the 6th day the difference between the control group and the PCB-fed group became much more remarkable. But thereafter no further reduc tion was seen, indicating a lower limit of vitamin A concentration in the liver of rats fed PCB. It was found that retinol binding protein in the serum of rats fed the 0.1% PCB diet decreased to one-half that of the control group on the 10th day of PCB ingestion, suggesting also a marked reduction in serum vitamin A level. Another experiment revealed that a decrease in hepatic vitamin A oc curred even at low PCB levels, but serum phospholipid did not respond at all to any PCB level examined until 7 days after PCB ingestion began. The mechanisms of sensitive response of vitamin A in the animals fed PCB are briefly discussed.