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标题：An Evaluation of the Bioavailability of Selenium in High-Selenium Yeast
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作者：Munehiro YOSHIDA ; Kenji FUKUNAGA ; Hiroshi TSUCHITA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1999
卷号：45
期号：1
页码：119-128
DOI：10.3177/jnsv.45.119
出版社：Center for Academic Publications Japan
摘要：The bioavailability of selenium (Se) in high-Se yeast (SeY) was evaluated by measuring tissue Se accumulation and glutathione peroxidase (GSHPx) activity. For 4 weeks, 4-week-old male wistar rats were fed a Torula yeast-based Se-deficient diet (basal diet) or a diet supplemented with a graded level (0.04, 0.08, 0.16, and 0.32μg/g) of Se as either sodium selenite or SeY, which was obtained from two different sources. Se supplementation did not influence growth, hematological values, or serum biochemical tests. Se contents and GSHPx activities in the liver, serum, and erythrocytes increased gradually with increases of the supplemented Se. At lower Se levels (0.04 and 0.08μg/g), selenite produced higher Se deposition and higher GSHPx activities than SeY did, but at a higher Se level (0.32μg/g), SeY showed higher measures. Strong corre-lations were detected between the supplementary Se levels and the tissue Se contents or GSHPX activities when the regression was fitted to this equation: R-R_b= m log X + k , where R represented tissue Se content or GSHPx activity in rats fed the diet supplemented with Se at X level, R _b corresponding mean value in rats fed the basal diet, m slope, and k constant. The bioavailability of Se in SeY, as assessed by slope ratio analysis using selenite as a reference Se, was 135% to 165% in the tissue Se content and 105% to 197% in the GSHPx activities. These results indicate that Se in SeY is more bioavailable than selenite Se, and therefore it is the preferred form for supplementation.
关键词：selenium;glutathione peroxidase;high-selenium yeast;bioavailability;selenite