文章基本信息

标题：Dietary Vitamin E Supplementation Does Not Inhibit Candida albicans Intestinal Translocation in Rats
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作者：Márcia Varella MORANDI ; Roberto MARTINEZ ; Hélio VANNUCCHI 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：1999
卷号：45
期号：2
页码：153-161
DOI：10.3177/jnsv.45.153
出版社：Center for Academic Publications Japan
摘要：Candida albicans translocation was determined in rats receiving a normal or vitamin E-supplemented and deficient diet submitted to mesenteric ischemia and reperfusion (MIR). The antioxidant effect of vitamin E on lipid peroxidation was also assessed. The animals were divided into six groups submitted to different diets for 30 d. Groups N, NI, NC and NIC were submitted to a normal diet and used as controls, and groups VITE and DEFE received a vitamin E-supplemented and vitamin E-deficient diet, respectively. Groups NIC, VITE and DEFE were submitted to MIR, inoculated with Candida albicans and sacrificed 24 h after the surgical procedure. The antioxidant effect of vitamin E was determined in the liver and gut mucosa using the TBARS method. Candida albicans translocation was assessed in lymph node, liver and kidney specimens. The results showed that lipid peroxidation was lower ( p <0.05) in the vitamin E-supplemented group. However, vitamin E supplementa-tion did not protect the rats against Candida albicans translocation (the translocation in the Group VITE was 100% for lymph nodes).
关键词：intestinal translocation;free radical;vitamin E;Candida albicans;mesenteric ischemia