文章基本信息

标题：Increased Cholesterol Absorption by Hyperlipidemia Atherosclerosis Prone (LAP) Japanese Quail
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作者：Hironori IWASAKI ; Hirosuke OKU ; Takayoshi TODA 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2000
卷号：46
期号：5
页码：235-239
DOI：10.3177/jnsv.46.235
出版社：Center for Academic Publications Japan
摘要：The present study describes the cholesterol absorption by hyperlipidemia ath-erosclerosis prone (LAP) Japanese quail to address their high susceptibility to experimental atherosclerosis. The apparent cholesterol absorption rate of LAP quail was compared with that ofcommercially available (CA) Japanese quail. After 14 d of cholesterol feeding by ga-vage, it was found that the cholesterol excretion of LAP quail was significantly lower than that of CA quail. The fecal excretion of bile acid and fat showed a similar tendency to that as shown with the case of cholesterol. The cholesterol feeding only increased the serum choles-terol level of LAP quail, and this trend holds true for the liver lipid concentration. The ex-pression level of liver cholesterol 7α-hydroxylase mRNA showed no difference between LAP and CA strains under the conditions of cholesterol loading. These results showed that the cholesterol absorption by LAP quail is significantly higher than that by CA quail, which may reasonably explain the higher susceptibility of this strain to experimental atherosclero-sis.
关键词：cholesterol feeding;atherosclerosis;absorption;excretion