文章基本信息

标题：Ascorbic Acid Protects against Peroxidative Modification of Low-Density Lipoprotein, Maintaining Its Recognition by LDL Receptors
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作者：Nagahiko SAKUMA ; Masae YOSHIKAWA ; Takeshi HIBINO 等
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2001
卷号：47
期号：1
页码：28-31
DOI：10.3177/jnsv.47.28
出版社：Center for Academic Publications Japan
摘要：Peroxidatively modified low-density lipoprotein (LDL) may contribute to ath-erosclerotic processes; therefore, protecting LDL. against peroxidation may thus reduce or re-tard the progression of atherosclerosis. We have evaluated the protective effects of ascorbic acid on copper-catalyzed LDL peroxidative modification. The protective effects of ascorbic acid on copper-catalyzed LDL peroxidative modification were examined by measurement of concentration of lipid hydroperoxides in LDL and by the provision of LDL cholesterol to lym-phocytes via LDL receptor-mediated pathway. The measurement of concentration of lipid hydroperoxides in LDL showed that ascorbic acid inhibited peroxidative modification of LDL. Also, ascorbic acid preserved the ability of LDL to be recognized by LDL receptors in periph-eral blood lymphocytes to the same extent as native LDL. These findings indicate that ascor-bic acid may protect LDL against peroxidative modification, maintaining its ability to act as a ligand for LDL receptors in vivo.
关键词：ascorbic acid;peroxidized LDL;LDL receptor